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HRID394476

反应详情

EQUATION

反应方程式

HRID 394476 的结构方程式

REACTANTS

反应物

1
结构：CS(=O)(=O)c1nccc(C2CC(=O)NN=C2c2cccc(C(F)(F)F)c2)n1
HCID18176613

未命名化合物

PRODUCTS

生成物

1
结构：CC(Nc1nccc([C@@H]2CC(=O)NN=C2c2cccc(C(F)(F)F)c2)n1)c1ccccc1
HCID70023896

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Compound 7 (5.00 g, 13.1 mmol), s-(−)-α-methylbenzylamine (3.37 mL, 26.2 mmol) and tetrahydrofuran (100 mL) were heated to reflux under argon for 24 h. The solvent was removed in vacuo. Purification by flash column chromatography (methylene chloride:methanol: ammonium hydroxide 98:2:0.2) gave Compound 8 as a foam: 5.0 g (9.6 mmol, 73%).

WORKUP

后处理

  1. temperatureto reflux under argon for 24 h
  2. customThe solvent was removed in vacuo
  3. customPurification by flash column chromatography (methylene chloride:methanol: ammonium hydroxide 98:2:0.2)