反应详情

温度

90 °C

Compound 6 (1.92 g, 5.26 mmol), 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (4.78 g, 21.0 mmol), and acetonitrile (30 mL) were combined under argon and heated at 90° C. for 1 h. The solution was cooled and the solvent was removed in vacuo. The crude product was purified by flash column chromatography (methylene chloride:methanol:ammonium hydroxide 95:5:0.5) to give a solid. Trituration with.Et2O EtOAc gave Compound 69: 1.60 g (4.4 mmol, 83%)

1. temperatureThe solution was cooled
2. customthe solvent was removed in vacuo
3. customThe crude product was purified by flash column chromatography (methylene chloride:methanol:ammonium hydroxide 95:5:0.5)
4. customto give a solid