Morpholine → HCID 18176619, compound

HRID 394481Notes

Reaction equation

[CH3:1][S:2][C:3]1[N:8]=[C:7]([C:9]2[CH:10]=[C:11](OS(C(F)(F)F)(=O)=O)[N:12]=[N:13][C:14]=2[C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)[CH:6]=[CH:5][N:4]=1.[NH:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1>>[CH3:1][S:2][C:3]1[N:8]=[C:7]([C:9]2[CH:10]=[C:11]([N:33]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)[N:12]=[N:13][C:14]=2[C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:23])([F:22])[F:24])[CH:16]=2)[CH:6]=[CH:5][N:4]=1

Participants

Reactant 2

HCID 8083Morpholine

HCID 86759096HCID 86759096, compound

Product 1

HCID 18176619HCID 18176619, compound

Conditions

Temperature: 80 °C

Procedure

Compound 74 (180 mg, 0.363 mmol) and morpholine (˜1 mL) were combined under Argon and heated to 80° C. for 2 h. Purification by flash column chromatography (hexane ethyl acetate 50:50) gave Compound 75 as an oil: 104 mg (0.240 mmol, 66%)

Workup

customPurification by flash column chromatography (hexane ethyl acetate 50:50)

Sources & evidence

ORD record: ord-04e1d7fcdd00408cb29f906af1ab0206
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06602872B1

Reaction notes

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