1-Benzyl-4-(N-Boc-amino)piperidine → 4-(N-Boc-amino)piperidine

HRID 394482Notes

Reaction equation

HRID 394482 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].C(O)C>[C:18]([O:17][C:15]([NH:14][CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:16])([CH3:21])([CH3:19])[CH3:20]

Participants

4

Reactant 1

HCID 44386181-Benzyl-4-(N-Boc-amino)piperidine

Product 1

HCID 7238334-(N-Boc-amino)piperidineYield 91.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Compound 79 (4.55 g, 15.7 mmol), 10% palladium on carbon (400 mg), and ethanol (100 mL) were combined and hydrogenated in a Parr jar at 63psi for 3d. The mixture was filtrated through celite, followed by removal of the solvent in vacuo to afford 2.87 g (14.4 mmol, 91.4%) of Compound 80.

Workup

  1. filtrationThe mixture was filtrated through celite
  2. customfollowed by removal of the solvent in vacuo

Sources & evidence

ORD record
ord-86a809d4425a40f9a9c7b2ab0717eaa7
Source dataset
uspto-grants-2003_08
Patent number
US06602872B1

Reaction notes

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