HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 394483Generated: October 28, 2026
Thiophenol → (s)-5-[2-(1-Phenylethylamino)pyrimidin-4-yl]-3-(phenylsulfanyl)-6-(3-trifluoromethylphenyl)pyridazine
https://huagongshe.com/reaction/394483
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (s)-6-Chloro-4-[2-(1-phenylethylamino)pyrimidin-4-yl]-3-(3-trifluoromethyl-phenyl)pyridazine | HCID 12070269 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (s)-5-[2-(1-Phenylethylamino)pyrimidin-4-yl]-3-(phenylsulfanyl)-6-(3-trifluoromethylphenyl)pyridazine | HCID 10186704 | 51% |
Reaction Steps
Compound 10 (100 mg, 0.220 mmol), thiophenol (˜200 μL), and diisopropylethylamine (100 mL) were combined under Ar and heated at 120° C. for 3 h. The mixture was purified by flash column chromatography (hexane:ethyl acetate 70:30) to afford a foam. Crystallization from hexane:ethyl acetate afforded 59 mg (0.112 mmol, 51%) of Compound 86.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06602872B1 |
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| Source dataset | uspto-grants-2003_08 |
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| ORD ID | ord-cbfb592bfe56437192e746d0dd6e2de4 |
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| Source note | uspto-grants-2003_08 |
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