反应详情

1 g of 3-hydroxy-benzenepropanoic acid is mixed in 20 ml of methanol and 8 drops of sulphuric acid, the reaction medium is taken to reflux for 2 hours then evaporated under reduced pressure and purified by chromatography eluting with an AcOEt/Cyclohexane mixture 50/50. 1.07 g of expected product is obtained.

1. temperatureto reflux for 2 hours
2. customthen evaporated under reduced pressure
3. custompurified by chromatography
4. washeluting with an AcOEt/Cyclohexane mixture 50/50