Dimethylformamide → HCID 18177123, compound
Reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]1[N:14]=[CH:15][N:16]([C:18]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:17]=1)[CH2:7][CH:6]([NH:37][S:38]([CH3:41])(=[O:40])=[O:39])[CH2:5]2.C[N:43]([CH3:46])C=O>>[C:46]([C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]1[N:14]=[CH:15][N:16]([C:18]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:17]=1)[CH2:7][CH:6]([NH:37][S:38]([C:41]1[CH:4]=[CH:3][CH:2]=[CH:11][CH:10]=1)(=[O:40])=[O:39])[CH2:5]2)#[N:43].[C:46]([C:22]1[CH:23]=[C:24]2[C:19](=[CH:20][CH:21]=1)[N:8]([CH2:12][C:13]1[N:14]=[CH:15][NH:16][CH:17]=1)[CH2:7][CH:6]([N:37]([CH2:5][C:4]1[CH:9]=[CH:10][CH:11]=[CH:2][CH:3]=1)[S:38]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)(=[O:40])=[O:39])[CH2:5]2)#[N:43]Participants
4
Procedure
The title compound (2.5 g, 75%) was obtained from compound N-[6-Cyano-1,2,3,4-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-quinolinyl]-N-(phenylmethyl)benzenesulfonamide (2.68 g, 5.3 mmol) in a manner similar to the preparation of N-[6-Bromo-1,2,3,4-tetrahydro-1-[[1-(triphenylmethyl)-1H-imidazol-4-yl]methyl]-3-quinolinyl]methanesulfonamide except dimethylformamide was employed instead of acetonitrile as the solvent. The white solid was used without further purification.
Sources & evidence
- ORD record
- ord-3bb1522c246d406e83ef73869938f940
- Source dataset
- uspto-grants-2003_08
- Patent number
- US06602883B1
Reaction notes
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