反应详情

1.4 g of N-(3,5-dichloropyridin-4-yl)-2-[1-(4-fluorobenzyl)-5-methoxyindol-3-yl]-2-oxoacetamide (3 mmol) is dissolved in 100 ml of dichloromethane. The solution is heated to reflux and treated with a solution of 14 mmol of BBr3 in 15 ml of dichloromethane with stirring. The reaction mixture is refluxed for 3 hours. After cooling, the solution is intensively stirred for 3 hours at 20° C. with 200 ml of an aqueous sodium hydrogencarbonate solution. The product crystallizes out, it is isolated, dried at 60° C. and recrystallized from 80 ml of ethanol.

1. temperatureThe solution is heated
2. temperatureto reflux
3. temperatureThe reaction mixture is refluxed for 3 hours
4. temperatureAfter cooling
5. customThe product crystallizes out
6. customit is isolated
7. customdried at 60° C.
8. customrecrystallized from 80 ml of ethanol