Hydrochloric Acid → HCID 18177205, compound

HRID 394581Notes

Reaction equation

HRID 394581 reaction equation
[CH3:1][N:2]1[N:6]=[N:5][C:4]([C:7]2[CH:8]=[C:9]3[C:13](=[CH:14][CH:15]=2)[NH:12][CH:11]=[CH:10]3)=[N:3]1.O.[NH:17]1[CH2:22][CH2:21][C:20](=O)[CH2:19][CH2:18]1.Cl.[OH-].[K+]>C(O)C>[CH3:1][N:2]1[N:6]=[N:5][C:4]([C:7]2[CH:8]=[C:9]3[C:13](=[CH:14][CH:15]=2)[NH:12][CH:11]=[C:10]3[C:20]2[CH2:21][CH2:22][NH:17][CH2:18][CH:19]=2)=[N:3]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 18177232HCID 18177232, compoundHCID 21584170Piperidin-4-one hydrate

Product 1

HCID 18177205HCID 18177205, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5-(2-methyltetrazol-5-yl)-1H-indole (2b) (40 g), piperidin-4-one, hydrate, hydrochloride (80 g) and potassium hydroxide (48 g) in ethanol (1000 mL) was boiled at reflux for 16 hours. After cooling to room temperature, precipitated material was filtered off and carefully washed with water. The remaining crystalline product was dried in vacuo at 80° C. leaving 41 g of crude title compound 3a which was used without further purification.

Workup

  1. temperatureat reflux for 16 hours
  2. customprecipitated material
  3. filtrationwas filtered off
  4. washcarefully washed with water
  5. customThe remaining crystalline product was dried in vacuo at 80° C.

Sources & evidence

ORD record
ord-ed7c4ce2af7c4480bc6ee3248069bbde
Source dataset
uspto-grants-2003_08
Patent number
US06602889B1

Reaction notes

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