反应详情

A solution of 5-(2-methyltetrazol-5-yl)-1H-indole (2b) (40 g), piperidin-4-one, hydrate, hydrochloride (80 g) and potassium hydroxide (48 g) in ethanol (1000 mL) was boiled at reflux for 16 hours. After cooling to room temperature, precipitated material was filtered off and carefully washed with water. The remaining crystalline product was dried in vacuo at 80° C. leaving 41 g of crude title compound 3a which was used without further purification.

1. temperatureat reflux for 16 hours
2. customprecipitated material
3. filtrationwas filtered off
4. washcarefully washed with water
5. customThe remaining crystalline product was dried in vacuo at 80° C.