反应详情

A mixture of 3-[4-[5-(2-methyltetrazol-5-yl)-1-(4-fluorophenyl)-1H-indol-3-yl]-1,2,3,6-tetrahydropyridin-1-yl]propionitril 15a, (3.5 g), sodium azide (2.5 g), and triethylamine hydrochloride (4.5 g) in DME (25 mL) was boiled at reflux for 16 hours. The solvent was evaporated and water (25 mL) and ethyl acetate (1-2 mL) were added after stirring for 0.5 hours the precipitated title compound 16a, was filtered off and dried. Yield 3.2 g, mp 131-132° C.

1. temperatureat reflux for 16 hours
2. customThe solvent was evaporated
3. additionwater (25 mL) and ethyl acetate (1-2 mL) were added
4. customprecipitated title compound 16a
5. filtrationwas filtered off
6. customdried