Fumarate → HCID 9869950, compound

HRID 394591Notes

Reaction equation

HRID 394591 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([C:17]4[N:18]=[N:19][N:20]([CH3:22])[N:21]=4)=[CH:14][CH:15]=3)[C:10]([C:23]3[CH2:24][CH2:25][N:26]([CH2:29][CH2:30][C:31]4[N:35](C)[N:34]=[N:33][N:32]=4)[CH2:27][CH:28]=3)=[CH:9]2)=[CH:4][CH:3]=1.[C:37]([O-])(=O)/C=C/C([O-])=O>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([C:17]4[N:18]=[N:19][N:20]([CH3:22])[N:21]=4)=[CH:14][CH:15]=3)[C:10]([C:23]3[CH2:24][CH2:25][N:26]([CH2:29][CH2:30][C:31]4[N:32]=[N:33][N:34]([CH3:37])[N:35]=4)[CH2:27][CH:28]=3)=[CH:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 5460307FumarateHCID 9891489HCID 9891489, compound

Product 1

HCID 9869950HCID 9869950, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Yield 0.9 g of 1-(4-fluorophenyl)-5-(2-methyltetrazol-5-yl)-3-[1-[2-(1-methyltetrazol-5-yl)-ethyl]-1,2,3,6-tetrahydropyridin-4-yl]-1H-indole, fumarate (17b). Mp 171-173° C. (ethanol). 1H NMR (DMSO-d6): δ 2.55-2.65 (m, 4H), 2.80 (t, 2H), 2.90 (t, 2H), 3.15 (t, 2H), 3.30 (broad s, 2H), 4.05 (s, 3H), 4.45 (s, 3H), 6.25 (broad s, 1H), 6.60 (s, 2H), 7.45 (t, 2H), 7.60-7.70 (m, 3H), 7.80 (s, 1H), 7.90 (d, 1H), 8.60 (s, 1H); MS m/z (%): 485 (MH+, 35), 346 (27), 140 (100).

Sources & evidence

ORD record
ord-15bd2900b4d94d9cada4ee157e866ff3
Source dataset
uspto-grants-2003_08
Patent number
US06602889B1

Reaction notes

Loading…