2-(3,4-Dihydro-2H-4-chromenylidene)acetonitrile → 2-(Chroman-4-yl)acetonitrile

Participants

Reaction Steps

The unsaturated compound obtained in Step A (Z+E mixture), solubilised in ethanol (20 ml), is introduced into the reactor of a Parr apparatus. 10% (by weight) palladium-on-carbon is then added. The double bond is hydrogenated at a pressure of 45 psi for 12 hours. The catalyst is removed by filtration; the solvent is then evaporated. The residual oil is purified on a silica column eluted by a mixture of AcOEt/PE 3/7. Colourless oil.

Provenance & Evidence