Water → HCID 18177467, compound

HRID 394678Notes

Reaction equation

HRID 394678 reaction equation
[CH2:1]([N:4]=[C:5]=[O:6])[CH2:2][CH3:3].[N-]=[C:8]=[O:9].[OH2:10].[C:11]1(C)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[O:10]1[C:16]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:9][CH:8]=[C:3]1[CH2:2][CH2:1][NH:4][C:5]([NH:4][CH2:1][CH2:2][CH3:3])=[O:6]

Participants

5

Reactant 4

HCID 962WaterHCID 1140TolueneHCID 61033Propyl isocyanateHCID 105034Isocyanate

Product 1

HCID 18177467HCID 18177467, compound

Procedure

The amine obtained in Preparation 7 is taken up in 25 ml of anhydrous toluene; 0.3 g (3.55 mmol) of n-propyl isocyanate is then added to that solution. After 2 hours of stirring under argon and at ambient temperature, the excess of isocyanate is neutralised with water; the solvent is then evaporated in vacuo. The title urea is obtained pure in the form of a white solid after passage over a silica column (eluant: AcOEt/PE: 70/30).

Workup

  1. customthe solvent is then evaporated in vacuo

Sources & evidence

ORD record
ord-ca3bee342dfa4fc89817457ec5aab747
Source dataset
uspto-grants-2003_08
Patent number
US06602903B2

Reaction notes

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