Water → HCID 18177467, compound

Participants

Reaction Steps

The amine obtained in Preparation 7 is taken up in 25 ml of anhydrous toluene; 0.3 g (3.55 mmol) of n-propyl isocyanate is then added to that solution. After 2 hours of stirring under argon and at ambient temperature, the excess of isocyanate is neutralised with water; the solvent is then evaporated in vacuo. The title urea is obtained pure in the form of a white solid after passage over a silica column (eluant: AcOEt/PE: 70/30).

Provenance & Evidence