Methanol → HCID 173244433, compound

HRID 394829Notes

Reaction equation

HRID 394829 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[C:9]1[C:10]2[NH:14][C:13]([C:15]([CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])=[C:16]3[N:39]=[C:19]([CH:20]=[C:21]4[NH:38][C:24](=[C:25]([CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[C:26]5[CH:27]=[CH:28][C:29]=1[N:30]=5)[CH:23]=[CH:22]4)[CH:18]=[CH:17]3)=[CH:12][CH:11]=2.CO.C([O-])(=O)C.[Zn+2:53].C([O-])(=O)C>C(Cl)(Cl)Cl>[Zn:53].[OH:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[C:9]1[C:10]2[NH:14][C:13]([C:15]([CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:46])=[C:16]3[N:39]=[C:19]([CH:20]=[C:21]4[NH:38][C:24](=[C:25]([CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[C:26]5[CH:27]=[CH:28][C:29]=1[N:30]=5)[CH:23]=[CH:22]4)[CH:18]=[CH:17]3)=[CH:12][CH:11]=2

Participants

5

Reactant 3

HCID 887MethanolHCID 11192Zinc AcetateHCID 173244476HCID 173244476, compound

Product 1

HCID 173244433HCID 173244433, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A starting compound (9)(14.0 mg, 22.8 μmol) was dissolved in 1 mL of chloroform. A saturated methanol solution of zinc acetate (0.3 mL) was added thereto and stirred at room temperature for 30 minutes. The chloroform solution was washed with water and solvent was removed by distillation. As a result, the compound (10) (14.6 mg) was obtained in a yield of 95%.

Workup

  1. washThe chloroform solution was washed with water and solvent
  2. customwas removed by distillation

Sources & evidence

ORD record
ord-c03876ca1fd44c9b940facc3e7b7b26d
Source dataset
uspto-grants-2003_08
Patent number
US06602998B2

Reaction notes

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