Acetic Acid → HCID 22734490, compound

HRID 394842Notes

Reaction equation

HRID 394842 reaction equation
[Cl:1][C:2]1[C:3]([CH3:15])=[C:4]([C:10]2[CH2:14][CH2:13][O:12][N:11]=2)[C:5]([S:8][CH3:9])=[CH:6][CH:7]=1.OO.[OH2:18].C(O)(=[O:21])C>O.O.[O-][W]([O-])(=O)=O.[Na+].[Na+]>[Cl:1][C:2]1[C:3]([CH3:15])=[C:4]([C:10]2[CH2:14][CH2:13][O:12][N:11]=2)[C:5]([S:8]([CH3:9])(=[O:21])=[O:18])=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 962WaterHCID 11195852HCID 11195852, compound

Product 1

HCID 22734490HCID 22734490, compound

Reagents, catalysts & solvents 1

HCID 150191Sodium Tungstate DihydrateCatalyst

Conditions

Temperature
0 °C

Procedure

1.4 g (6.2 mmol) of 3-(3-chloro-2-methyl-6-methylthiophenyl)-4,5-dihydroisoxazole are dissolved in 3 ml of glacial acetic acid, and 30.7 mg of sodium tungstate dihydrate are added. At 25-40° C., 2.1 g (18.6 mmol) of hydrogen peroxide are added dropwise, and the reaction mixture is stirred for 3 h. The reaction mixture is then poured into 1.5 ml of water, the mixture is cooled to 0° C. and the resulting precipitate is filtered off with suction, washed five times with 10 ml of water and dried under reduced pressure. This gives 1.23 g of product.

Workup

  1. filtrationthe resulting precipitate is filtered off with suction
  2. washwashed five times with 10 ml of water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-4f119bd712714c7c8566d7065d483554
Source dataset
uspto-grants-2003_08
Patent number
US06603017B2

Reaction notes

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