4,4,4-Trifluoro-1-[4-(2-furyl)phenyl]butane-1,3-dione → 5-[5-[3-Chloro-4-(1,3-oxazol-2-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide

HRID 394859Notes

Reaction equation

HRID 394859 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:13](=O)[CH2:14][C:15](=O)[C:16]([F:19])([F:18])[F:17])[CH:5]=[CH:6][C:7]=1[C:8]1[O:9][CH:10]=[CH:11][N:12]=1.FC(F)(F)C(=O)CC(C1C=CC(C2OC=CC=2)=CC=1)=O.Cl.[NH:43]([C:45]1[CH:46]=[CH:47][C:48]([S:51]([NH2:54])(=[O:53])=[O:52])=[N:49][CH:50]=1)[NH2:44]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:13]2[N:43]([C:45]3[CH:46]=[CH:47][C:48]([S:51]([NH2:54])(=[O:53])=[O:52])=[N:49][CH:50]=3)[N:44]=[C:15]([C:16]([F:19])([F:18])[F:17])[CH:14]=2)[CH:5]=[CH:6][C:7]=1[C:8]1[O:9][CH:10]=[CH:11][N:12]=1

Participants

4

Reactant 3

HCID 121141604,4,4-Trifluoro-1-[4-(2-furyl)phenyl]butane-1,3-dioneHCID 223138295-Hydrazino-2-pyridinesulfonamide hydrochlorideHCID 223138391-[3-Chloro-4-(1,3-oxazol-2-yl)phenyl]-4,4,4-trifluoro-1,3-butanedione

Product 1

HCID 102270645-[5-[3-Chloro-4-(1,3-oxazol-2-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide

Procedure

The subtitle compound was prepared according to the procedure of Example 1 (Step 2) using 1-[3-chloro-4-(1,3-oxazol-2-yl)phenyl]-4,4,4-trifluoro-1,3-butanedione, instead of 4,4,4-trifluoro-1-[4-(2-furyl)phenyl]butane-1,3-dione and 5-hydrazino-2-pyridinesulfonamide hydrochloride instead of 2-hydrazino-5-sulfamoylpyridine dihydrochloride.

Sources & evidence

ORD record
ord-0b64be91799844b496292557ec8ff252
Source dataset
uspto-grants-2003_08
Patent number
US06603008B1

Reaction notes

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