HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-[4-Chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-{4-Chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide | HCID 12096591 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-[4-Chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide hydrochloride | HCID 22313779 | 148.7% |
Reaction Steps
To a solution of 5-{4-chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide (200 mg, 0.412 mmol) in dichloromethane (6 ml) was added methanolic hydrochloric acid (2 ml) at room temperature. The solution stood for a while and a formed solid was collected to give 160 mg (74%) of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06603008B1 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-266061c54ff549fb9505b7b1b67b8bf7 |
| Source note | uspto-grants-2003_08 |