Hydrochloric Acid → 5-[4-Chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide hydrochloride

HRID 394863Notes

Reaction equation

HRID 394863 reaction equation
[Cl:1][C:2]1[C:3]([C:28]([F:31])([F:30])[F:29])=[N:4][N:5]([C:18]2[CH:19]=[CH:20][C:21]([S:24]([NH2:27])(=[O:26])=[O:25])=[N:22][CH:23]=2)[C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[CH:15][S:16][CH:17]=2)=[CH:9][CH:8]=1.Cl>ClCCl>[ClH:1].[Cl:1][C:2]1[C:3]([C:28]([F:31])([F:29])[F:30])=[N:4][N:5]([C:18]2[CH:19]=[CH:20][C:21]([S:24]([NH2:27])(=[O:25])=[O:26])=[N:22][CH:23]=2)[C:6]=1[C:7]1[CH:8]=[CH:9][C:10]([C:13]2[N:14]=[CH:15][S:16][CH:17]=2)=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 120965915-{4-Chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide

Product 1

HCID 223137795-[4-Chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2-pyridinesulfonamide hydrochlorideYield 148.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5-{4-chloro-5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide (200 mg, 0.412 mmol) in dichloromethane (6 ml) was added methanolic hydrochloric acid (2 ml) at room temperature. The solution stood for a while and a formed solid was collected to give 160 mg (74%) of the title compound as a white solid.

Workup

  1. customa formed solid was collected

Sources & evidence

ORD record
ord-266061c54ff549fb9505b7b1b67b8bf7
Source dataset
uspto-grants-2003_08
Patent number
US06603008B1

Reaction notes

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