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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 394869Generated: October 29, 2026

Hydrochloric Acid → 5-{5-[4-(1,3-Thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide hydrochloride

https://huagongshe.com/reaction/394869

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant5-{5-[4-(1,3-Thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamideHCID 10204319—
SolventDichloromethaneHCID 6344—
Product5-{5-[4-(1,3-Thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide hydrochlorideHCID 2231385292%

Reaction Steps

To a solution of 5-{5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide (470 mg, 1.04 mmol) in dichloromethane (6 ml) was added methanolic hydrochloric acid (4 ml) at room temperature. After evaporation, the residue obtained was recrystallized from methanol/diethyl ether to give 467 mg (92%) of the title compound as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06603008B1
Source datasetuspto-grants-2003_08
ORD IDord-5466e0d4766640bf97d39b0e5905013e
Source noteuspto-grants-2003_08