HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-{5-[4-(1,3-Thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-{5-[4-(1,3-Thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide | HCID 10204319 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-{5-[4-(1,3-Thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide hydrochloride | HCID 22313852 | 92% |
Reaction Steps
To a solution of 5-{5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide (470 mg, 1.04 mmol) in dichloromethane (6 ml) was added methanolic hydrochloric acid (4 ml) at room temperature. After evaporation, the residue obtained was recrystallized from methanol/diethyl ether to give 467 mg (92%) of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06603008B1 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-5466e0d4766640bf97d39b0e5905013e |
| Source note | uspto-grants-2003_08 |