Hydrochloric Acid → 5-{5-[4-(1,3-Thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide hydrochloride

HRID 394869Notes

Reaction equation

HRID 394869 reaction equation
[S:1]1[CH:5]=[C:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]3[N:16]([C:17]4[CH:18]=[CH:19][C:20]([S:23]([NH2:26])(=[O:25])=[O:24])=[N:21][CH:22]=4)[N:15]=[C:14]([C:27]([F:30])([F:29])[F:28])[CH:13]=3)=[CH:8][CH:7]=2)[N:3]=[CH:2]1.[ClH:31]>ClCCl>[ClH:31].[S:1]1[CH:5]=[C:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]3[N:16]([C:17]4[CH:18]=[CH:19][C:20]([S:23]([NH2:26])(=[O:24])=[O:25])=[N:21][CH:22]=4)[N:15]=[C:14]([C:27]([F:28])([F:29])[F:30])[CH:13]=3)=[CH:8][CH:7]=2)[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 102043195-{5-[4-(1,3-Thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide

Product 1

HCID 223138525-{5-[4-(1,3-Thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide hydrochlorideYield 92%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5-{5-[4-(1,3-thiazol-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}-2-pyridinesulfonamide (470 mg, 1.04 mmol) in dichloromethane (6 ml) was added methanolic hydrochloric acid (4 ml) at room temperature. After evaporation, the residue obtained was recrystallized from methanol/diethyl ether to give 467 mg (92%) of the title compound as a white solid.

Workup

  1. customAfter evaporation
  2. customthe residue obtained
  3. customwas recrystallized from methanol/diethyl ether

Sources & evidence

ORD record
ord-5466e0d4766640bf97d39b0e5905013e
Source dataset
uspto-grants-2003_08
Patent number
US06603008B1

Reaction notes

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