HCID 17812156, compound → HCID 22313831, compound

HRID 394882Notes

Reaction equation

HRID 394882 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[CH:20][C:21]([S:24]([NH2:27])(=[O:26])=[O:25])=[N:22][CH:23]=3)[N:16]=[C:15]([C:28]([F:31])([F:30])[F:29])[CH:14]=2)[CH:5]=[CH:6][C:7]=1[C:8]1[S:12][CH:11]=[N:10][CH:9]=1.[ClH:32].CO>>[ClH:32].[F:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[CH:20][C:21]([S:24]([NH2:27])(=[O:26])=[O:25])=[N:22][CH:23]=3)[N:16]=[C:15]([C:28]([F:30])([F:31])[F:29])[CH:14]=2)[CH:5]=[CH:6][C:7]=1[C:8]1[S:12][CH:11]=[N:10][CH:9]=1

Participants

3

Reactant 2

HCID 17812156HCID 17812156, compoundHCID 21893726Hydrochloride methanol

Product 1

HCID 22313831HCID 22313831, compoundYield 92.1%

Procedure

5-(5-(3-Fluoro-4-(1,3-thiazol-5-yl)phenyl)-3-trifluoromethyl-1H-pyrazol-1-yl)-2-pyridinesulfonamide (236 mg, 0.50 mmol) was dissolved with HCl—MeOH and the solvent was removed. The residue was washed with ethyl acetate to afford 233 mg (92.1%) of the titled compound as a slight yellow solid.

Workup

  1. customthe solvent was removed
  2. washThe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-ee48211e1c204b358e7500515897b415
Source dataset
uspto-grants-2003_08
Patent number
US06603008B1

Reaction notes

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