Piperidine → HCID 57895130, compound

HRID 39490Notes

Reaction equation

HRID 39490 reaction equation
CS(OC(C1C=NC(NC(C2(C3C=CC4OCOC=4C=3)CC2)=O)=CC=1)C1C=CC=C[C:8]=1[O:13][CH3:14])(=O)=O.N1CCC[CH2:38][CH2:37]1.[O:42]1[C:46]2[CH:47]=[CH:48][C:49]([C:51]3([C:54]([NH:56][C:57]4[CH:62]=[CH:61][C:60]([CH:63]([N:72]([CH3:74])[CH3:73])[C:64]5[CH:69]=[CH:68][CH:67]=[CH:66][C:65]=5[O:70][CH3:71])=[CH:59][N:58]=4)=[O:55])[CH2:53][CH2:52]3)=[CH:50][C:45]=2[O:44][CH2:43]1>>[O:42]1[C:46]2[CH:47]=[CH:48][C:49]([C:51]3([C:54]([NH:56][C:57]4[CH:62]=[CH:61][C:60]([CH:63]([N:72]5[CH2:73][CH2:38][CH2:37][C@H:74]5[CH2:8][O:13][CH3:14])[C:64]5[CH:69]=[CH:68][CH:67]=[CH:66][C:65]=5[O:70][CH3:71])=[CH:59][N:58]=4)=[O:55])[CH2:53][CH2:52]3)=[CH:50][C:45]=2[O:44][CH2:43]1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 442364971-(benzo[d][1,3]dioxol-5-yl)-N-(5-((dimethylamino)(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamideHCID 57895126(6-(1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)pyridin-3-yl)(2-methoxyphenyl)methyl methanesulfonate

Product 1

HCID 57895130HCID 57895130, compound

Procedure

1-(Benzo[d][1,3]dioxol-5-yl)-N-(5-(((S)-2-(methoxymethyl)pyrrolidin-1-yl)(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamide was prepared from (6-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)pyridin-3-yl)(2-methoxyphenyl)methyl methanesulfonate and piperidine in a manner analogous to that of 1-(benzo[d][1,3]dioxol-5-yl)-N-(5-((dimethylamino)(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamide.

Sources & evidence

ORD record
ord-49f16367a57d4de8a3bb982f40dafb23
Source dataset
uspto-grants-2013_09
Patent number
US08524910B2

Reaction notes

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