Benzyloxytrimethylsilane → HCID 69682645, compound

HRID 394924Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:21])[C:5](=[O:20])[C:6]1[CH:15]=[CH:14][C:13]2[C:12]([CH3:17])([CH3:16])[CH2:11][CH2:10][C:9]([CH3:19])([CH3:18])[C:8]=2[CH:7]=1)[CH3:2].[CH2:22](O[Si](C)(C)C)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:1]([O:3][C:4](=[O:21])[CH:5]([O:20][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:6]1[CH:15]=[CH:14][C:13]2[C:12]([CH3:16])([CH3:17])[CH2:11][CH2:10][C:9]([CH3:19])([CH3:18])[C:8]=2[CH:7]=1)[CH3:2]

Participants

Reactant 2

HCID 518982Benzyloxytrimethylsilane

HCID 21267561HCID 21267561, compound

Product 1

HCID 69682645HCID 69682645, compoundYield 37.9%

Procedure

2.5 g of oxo-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetic acid ethyl ester (example 15.1.a) were reacted with 1.5 g of benzyloxytrimethylsilane according to the procedure given in example 15.1.b) to give 1.2 g of (RS)-benzyloxy-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetic acid ethyl ester as slightly yellow oil.

Sources & evidence

ORD record: ord-bf540fb937c4490ca3cf8db3adbbcf0f
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06603012B2

Reaction notes

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