2,3-Dimethoxybenzaldehyde → 2,3-Dimethoxy-4'-prop-2-enyloxychalcone

Participants

Reaction Steps

1.76 g (10 mmol) of 4-allyloxyacetophenone and 1.66 g (10 mmol) of 2,3-dimethoxy-benzaldehyde were under an inert atmosphere (argon) dissolved in 10 ml of dry freshly distilled ethanol, and 100 mg of sodium hydroxide was added to the solution. The mixture was left under stirring for 23 h and concentrated in vacuo. The crystalline residue was recrystallized from methanol-water to give 2.92 g (90%) of 2,3-dimethoxy-4′-prop-2-enyloxychalcone, m.p. 98-99° C.

Provenance & Evidence