Ammonium Acetate → 3-[(2-Chloro-4-iodophenyl)amino]isonicotinamide

HRID 39520Notes

Reaction equation

HRID 39520 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12](O)=[O:13].C([O-])(=O)C.[NH4+:23]>>[Cl:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH2:23])=[O:13]

Participants

3

Reactant 2

HCID 517165Ammonium AcetateHCID 576496513-[(2-Chloro-4-iodophenyl)amino]isonicotinic acid2×

Product 1

HCID 116177013-[(2-Chloro-4-iodophenyl)amino]isonicotinamide

Procedure

3-[(2-chloro-4-iodophenyl)amino]isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 6 mmol of 3-[(2-chloro-4-iodophenyl)amino]isonicotinic acid (intermediate 2) and 12 mmol of ammonium acetate. LC/MS [8.29 min; 374 (M+1)]

Workup

  1. customLC/MS [8.29 min; 374 (M+1)]

Sources & evidence

ORD record
ord-563ca3b690d34ef0b5c1c242ff25cd1c
Source dataset
uspto-grants-2013_09
Patent number
US08524911B2

Reaction notes

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