Potassium Carbonate → HCID 18710218, compound

HRID 395217Notes

Reaction equation

HRID 395217 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([C:16]#[C:17][Si](C)(C)C)[CH:7]=[CH:8][C:9]=1[CH2:10][O:11][C:12]1([CH3:15])[CH2:14][CH2:13]1)([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:16]([C:6]1[CH:7]=[CH:8][C:9]([CH2:10][O:11][C:12]2([CH3:15])[CH2:13][CH2:14]2)=[C:4]([CH:1]([CH3:3])[CH3:2])[CH:5]=1)#[CH:17]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 69548710[3-Isopropyl-4-(1-methyl-cyclopropoxymethyl)-phenylethynyl]-trimethylsilane2×

Product 1

HCID 18710218HCID 18710218, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [3-isopropyl-4-(1-methyl-cyclopropoxymethyl)-phenylethynyl]-trimethylsilane (Intermediate 165, 110.0 mg, 0.37 mmol) in methanol (6 mL) was treated with potassium carbonate (80.0 mg, 0.58 mmol) and stirred overnight at ambient temperature. The crude alkyne (84 mg, 100%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-b051a9d206e24cb694f610dccdd5ca43
Source dataset
uspto-grants-2003_08
Patent number
US06603019B2

Reaction notes

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