反应详情

温度

40 °C

To an autoclave is added the product of example 2 (7.0 kg, 24 moles, 1.0 eq). Raney Nickel (1.4 kg) is activated and suspended in 4 L of THF. The slurry is added to the autoclave followed by additional THF (66 L). The mixture is heated at 40° C. and under 40 psi H2 till completion. The mixture is filtered and the filtrate is directly used in the next step. A small portion of the filtrate is concentrated and recrystallized in isopropanol to give the title compound.

1. additionThe slurry is added to the autoclave
2. filtrationThe mixture is filtered
3. concentrationA small portion of the filtrate is concentrated
4. customrecrystallized in isopropanol