反应详情

N-Methylaniline (2.7g, 0.025 mol) was dissolved in 80 ml of toluene and about 30 ml of the solvent was distilled off in order to obtain a dry solution. 1,2-Dihydro-4-hydroxy-5-methoxy-1-methyl-2-oxo-quinoline-3-carboxylic acid ethyl ester (2.7 g, 0.01 mol) was added to the boiling solution. The ethanol formed during the reaction was distilled off together with some toluene for about 4 hours. The mixture was cooled to room temperature. The precipitate was collected, washed with cold toluene and hexane and dried to give the title compound (2.8 g), yield 83%.

1. distillationabout 30 ml of the solvent was distilled off in order
2. customto obtain a dry solution
3. distillationwas distilled off together with some toluene for about 4 hours
4. customThe precipitate was collected
5. washwashed with cold toluene and hexane
6. customdried