Sodium Iodide → HCID 22668889, compound

HRID 395407Notes

Reaction equation

HRID 395407 reaction equation
[F:1][CH:2]([F:23])[C:3]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[C:7]([CH2:13][CH:14]([CH3:16])[CH3:15])[C:6]([CH2:17]Cl)=[C:5]([C:19]([F:22])([F:21])[F:20])[N:4]=1.[I-:24].[Na+]>CC(C)=O>[F:1][CH:2]([F:23])[C:3]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[C:7]([CH2:13][CH:14]([CH3:16])[CH3:15])[C:6]([CH2:17][I:24])=[C:5]([C:19]([F:22])([F:21])[F:20])[N:4]=1

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 22668817Methyl 2-(difluoromethyl)-5-(chloromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate

Product 1

HCID 22668889HCID 22668889, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Reaction of methyl 2-(difluoromethyl)-5-(chloromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridine-carboxylate (U.S. Pat. No. 5,169,432 example 3) with sodium iodide in refluxing acetone according to the procedure known to those in the art yielded the product.

Workup

  1. customyielded the product

Sources & evidence

ORD record
ord-3885870b736d47c19dbc5be86d5cfd51
Source dataset
uspto-grants-2003_08
Patent number
US06605624B1

Reaction notes

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