反应详情

温度

80 °C

To a solution of 1-(ethoxycarbonyl)-4-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methylamino]piperidine (400 mg) in acetonitrile (5 mL) was added potassium carbonate (13 mg) and iodoethane (145 mg). The mixture was placed in sealed vessel and stirred at 80° C. for 2 hours. After removing the solvent in vacuo, ethyl acetate was added, washed with water and brine, dried over anhydrous sodium sulfate and evaporated. The residue was subjected to a column of silica gel using chloroform-methanol (30:1) as an eluent. Fractions containing the product were collected and evaporated to give the title compound as yellow syrup.

1. customThe mixture was placed in sealed vessel
2. customAfter removing the solvent in vacuo, ethyl acetate
3. additionwas added
4. washwashed with water and brine
5. dry with materialdried over anhydrous sodium sulfate
6. customevaporated
7. additionFractions containing the product
8. customwere collected
9. customevaporated