Propargylamine → HCID 22557994, compound

HRID 395495Notes

Reaction equation

HRID 395495 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][C:23](=O)[CH2:22][CH2:21]3)[CH:16]=[CH:15][N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[CH2:27]([NH2:30])[C:28]#[CH:29]>>[CH2:27]([NH:30][CH:23]1[CH2:24][CH2:25][N:20]([CH2:19][C:17]2[CH:16]=[CH:15][N:14]=[C:13]([C:5]3[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:18]=2)[CH2:21][CH2:22]1)[C:28]#[CH:29]

Participants

3

Reactant 2

HCID 239041PropargylamineHCID 22557811[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl-4-piperidone

Product 1

HCID 22557994HCID 22557994, compound

Procedure

1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]-4-piperidone (400 mg) and propargylamine (80 mg) were reacted in the same manner as described in Preparation Example 25 to give the title compound.

Workup

  1. customas described in Preparation Example 25

Sources & evidence

ORD record
ord-cd761dd445f34d9ebf2b6bc498f8552b
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

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