4-(Methylthio)aniline → 1-(Tert-butoxycarbonyl)-4-[[4-(methylthio)phenyl]amino]piperidine

HRID 395530Notes

Reaction equation

HRID 395530 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:15][S:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:21][C:20]2[CH:22]=[CH:23][C:17]([S:16][CH3:15])=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 660384-(Methylthio)anilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 225580351-(Tert-butoxycarbonyl)-4-[[4-(methylthio)phenyl]amino]piperidine

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (5.00 g) and 4-(methylthio)aniline (3.33 g) was treated in the same manner as described in Preparation Example 37 to give white powder of the title compound.

Workup

  1. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-2f1fe48e8a7e479dbfa1b3f51852b391
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

Loading…