p-Toluidine → para-methyl 4-Anilino-1-Boc-piperidine

HRID 395533Notes

Reaction equation

HRID 395533 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:15][C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 7813p-ToluidineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 22557837para-methyl 4-Anilino-1-Boc-piperidine

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (5.00 g) and p-toluidine (2.56 g) was treated in the same manner as described in Preparation Example 37 to give white powder of the title compound.

Workup

  1. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-a784fe0bb3fd48dd8f417999f9cb0fbc
Source dataset
uspto-grants-2003_08
Patent number
US06605620B1

Reaction notes

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