Ammonium Hydroxide → HCID 10198772, compound

HRID 395577Notes

Reaction equation

HRID 395577 reaction equation
C[O:2][C:3]([C:5]1[CH:19]=[CH:18][C:8]2[O:9][CH:10]=[C:11]([CH2:12][CH2:13][NH:14][C:15](=[O:17])[CH3:16])[C:7]=2[CH:6]=1)=O.[OH-].[NH4+:21]>>[C:15]([NH:14][CH2:13][CH2:12][C:11]1[C:7]2[CH:6]=[C:5]([C:3]([NH2:21])=[O:2])[CH:19]=[CH:18][C:8]=2[O:9][CH:10]=1)(=[O:17])[CH3:16]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 18175044HCID 18175044, compound

Product 1

HCID 10198772HCID 10198772, compound

Conditions

Temperature
60 °C

Procedure

The ester (0.1 mol) obtained in Example 62, dissolved in an aqueous 20% ammonium hydroxide solution (50 ml), is heated for 5 hours at 60° C. The reaction mixture is cooled and is then evaporated to dryness. The residue obtained is purified by chromatography on a silica gel column.

Workup

  1. temperatureThe reaction mixture is cooled
  2. customis then evaporated to dryness
  3. customThe residue obtained
  4. customis purified by chromatography on a silica gel column

Sources & evidence

ORD record
ord-d8e8f37966bf45f6b45d007c625f1d63
Source dataset
uspto-grants-2003_08
Patent number
US06605632B1

Reaction notes

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