反应详情

4-Methylaminophenol sulfate and equivalent 4-acetamidobenzenesulfonyl chloride and double equivalent triethylamine were reacted in ethanol at room temperature for 4 hours. After the solvent was removed in vacuo, the residue was extracted with diethyl ether. The ether layer was washed successively with 2 N hydrochloric acid, saturated aqueous NaHCO3 solution and water, then dried over anhydrous Na2SO4 The solvent was removed and the residue was recrystallized from ethanol to give N-(4-hydroxyphenyl)-N-methyl-4-acetamidobenzenesulfonamide, mp 202-203° C.

1. customAfter the solvent was removed in vacuo
2. extractionthe residue was extracted with diethyl ether
3. washThe ether layer was washed successively with 2 N hydrochloric acid, saturated aqueous NaHCO3 solution and water
4. dry with materialdried over anhydrous Na2SO4 The solvent
5. customwas removed
6. customthe residue was recrystallized from ethanol