Hydrochloric Acid → 4-(4-Chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-(3-(2-methylphenoxy)propyl)oxazole hydrochloride

HRID 395649Notes

Reaction equation

HRID 395649 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([N:24]3[CH:28]=[CH:27][N:26]=[C:25]3[CH3:29])[O:11][C:12]=2[CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH3:23])=[CH:4][CH:3]=1.Cl>CC(C)=O>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([N:24]3[CH:28]=[CH:27][N:26]=[C:25]3[CH3:29])[O:11][C:12]=2[CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH3:23])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 98876724-(4-Chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-[3-(2-methylphenoxy)propyl]oxazole

Product 1

HCID 234318104-(4-Chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-(3-(2-methylphenoxy)propyl)oxazole hydrochloride

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a mixture of 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-(3-(2-methylphenoxy)propyl)oxazole (1.0 g) and acetone (10 ml), conc. hydrochloride (0.3 ml) was added, which was allowed to stand at room temperature. The precipitated crystals were filtered (0.97 g). Recrystallization from ethanol gave 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-(3-(2-methylphenoxy)propyl)oxazole hydrochloride.

Workup

  1. additionwas added
  2. customto stand at room temperature
  3. filtrationThe precipitated crystals were filtered (0.97 g)
  4. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-5c6b023267924851a85d103b41563258
Source dataset
uspto-grants-2003_08
Patent number
US06605629B1

Reaction notes

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