反应详情

To a mixture of ethyl 6-(4-fluoro-1-naphthyl)-5-hydroxy-6-oxohexanoate (19.0 g), pyridine (5.50 g) and tetrahydrofuran (100 ml) was added dropwise phenyl chlorocarbonate (10.8 g) with stirring under ice-cooling. After 16 hours of stirring at room temperature, the reaction mixture was concentrated, diluted with ethyl acetate (400 ml) and washed with water (200 ml). The organic layer was dried over anhydrous magnesium sulfate, and concentrated to give ethyl 6-(4-fluoro-1-naphthyl)-6-oxo-5-phenoxycarbonyloxyhexanoate as a yellow oil (26.3 g, 96%).

1. temperaturecooling
2. stirringAfter 16 hours of stirring at room temperature
3. concentrationthe reaction mixture was concentrated
4. additiondiluted with ethyl acetate (400 ml)
5. washwashed with water (200 ml)
6. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
7. concentrationconcentrated