3-Amino-1-propanol → 2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(3-hydroxy-propyl)-isonicotinamide

HRID 39568Notes

Reaction equation

HRID 39568 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([I:18])=[CH:14][C:13]=2[F:19])=[CH:9][N:10]=1)[C:5]([OH:7])=O.[NH2:20][CH2:21][CH2:22][CH2:23][OH:24]>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([I:18])=[CH:14][C:13]=2[F:19])=[CH:9][N:10]=1)[C:5]([NH:20][CH2:21][CH2:22][CH2:23][OH:24])=[O:7]

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 576496492-Bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid

Product 1

HCID 115694932-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(3-hydroxy-propyl)-isonicotinamide

Procedure

2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(3-hydroxy-propyl)-isonicotinamide was synthesized according to General method 3, starting with 145 mg (0.33 mmol) of 2-bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid and 62 mg (0.82 mmol) of 3-Amino-propan-1-ol. LC/MS: [9.15 min, 494, 496]

Workup

  1. custom[9.15 min, 494, 496]

Sources & evidence

ORD record
ord-07243f61c94047f395048d2eb7c30b24
Source dataset
uspto-grants-2013_09
Patent number
US08524911B2

Reaction notes

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