反应详情

A pressure tube was charged with N-(4-methoxyphenyl)-2-aminobenzamide (500 mg, 2.07 mmol), 2,3-napthalenedicarboxylic anhydride (409 mg, 2.07 mmol), and tetrahydrofuran (10 mL). The resultant slurry was then placed in a bath heated to 110 C for 16 h. After cooling to ambient temperature and concentration to ½ of the solution volume, the product was triturated with 50% hexanes/50% ethyl acetate and the resulting solid collected by filtration. Recrystallization from hexanes/ethyl acetate yielded 476 mg (55%) of the title compound.

1. customThe resultant slurry was then placed in a bath
2. temperatureheated to 110 C for 16 h
3. concentrationconcentration
4. customthe product was triturated with 50% hexanes/50% ethyl acetate
5. filtrationthe resulting solid collected by filtration
6. customRecrystallization from hexanes/ethyl acetate