2-Amino-1,3-thiazole-5-carboxylic acid → N1-(2-Aminothiazol-5-ylcarbonyl)-N2-(4-tert-butylbenzoyl)-1,2-benzenediamine

HRID 395776Notes

Reaction equation

HRID 395776 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:7]([OH:9])=O)=[CH:5][N:6]=1.[C:10]([C:14]1[CH:29]=[CH:28][C:17]([C:18]([NH:20][C:21]2[C:22]([NH2:27])=[CH:23][CH:24]=[CH:25][CH:26]=2)=[O:19])=[CH:16][CH:15]=1)([CH3:13])([CH3:12])[CH3:11]>>[NH2:1][C:2]1[S:3][C:4]([C:7]([NH:27][C:22]2[C:21]([NH:20][C:18](=[O:19])[C:17]3[CH:28]=[CH:29][C:14]([C:10]([CH3:12])([CH3:11])[CH3:13])=[CH:15][CH:16]=3)=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:9])=[CH:5][N:6]=1

Participants

3

Reactant 2

HCID 3152432-Amino-1,3-thiazole-5-carboxylic acidHCID 1133079N-(2-aminophenyl)-4-tert-butylbenzamide

Product 1

HCID 54559603N1-(2-Aminothiazol-5-ylcarbonyl)-N2-(4-tert-butylbenzoyl)-1,2-benzenediamineYield 13%

Procedure

Using the procedure described in Example 102, Part A, 2-aminothiazole-5-carboxylic acid (1.0 mmol) and N1-(4-tert-butylbenzoyl)-1,2-benzenediamine (1.5 mmol) yielded 50 mg (13%) of the title compound.

Sources & evidence

ORD record
ord-ba8e437fca234e11835b796add25610c
Source dataset
uspto-grants-2003_08
Patent number
US06605626B2

Reaction notes

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