2-Morpholinoethylamine → 2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(2-morpholin-4-yl-ethyl)-isonicotinamide

HRID 39582Notes

Reaction equation

HRID 39582 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([I:18])=[CH:14][C:13]=2[F:19])=[CH:9][N:10]=1)[C:5]([OH:7])=O.[N:20]1([CH2:26][CH2:27][NH2:28])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([I:18])=[CH:14][C:13]=2[F:19])=[CH:9][N:10]=1)[C:5]([NH:28][CH2:27][CH2:26][N:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1)=[O:7]

Participants

3

Reactant 2

HCID 4082852-MorpholinoethylamineHCID 576496492-Bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid

Product 1

HCID 116853762-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(2-morpholin-4-yl-ethyl)-isonicotinamide

Procedure

2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(2-morpholin-4-yl-ethyl)-isonicotinamide was synthesized according to the General Method 3 starting with 145 mg (0.33 mmol) of 2-bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid and 108 mg (0.83 mmol) of 2-morpholin-4-yl-ethylamine. Yield: 95 mg, 52%. LC/MS: [7.08 min, 550, 552 (M+1)]

Workup

  1. custom[7.08 min, 550, 552 (M+1)]

Sources & evidence

ORD record
ord-d9977919c392446991bbfceb5c505eab
Source dataset
uspto-grants-2013_09
Patent number
US08524911B2

Reaction notes

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