2-amino-N-(4-chlorophenyl)benzamide → N-{2-[(4-chloroanilino)carbonyl]phenyl}isonicotinamide

HRID 395842Notes

Reaction equation

HRID 395842 reaction equation
[NH2:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)=[O:5].Cl.[C:19](Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1>>[N:23]1[CH:24]=[CH:25][C:20]([C:19]([NH:1][C:2]2[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=2[C:4]([NH:6][C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=2)=[O:5])=[O:26])=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 6704722-amino-N-(4-chlorophenyl)benzamideHCID 12262826Isonicotinoyl chloride hydrochloride

Product 1

HCID 1099265N-{2-[(4-chloroanilino)carbonyl]phenyl}isonicotinamideYield 91%

Procedure

Using the procedure described in Example 93, Part A, 2-amino-N-(4-chlorophenyl)benzamide (5 g, 20.3 mmol) and isonicotinoyl chloride hydrochloride (3.97 g, 22.3 mmol) yielded 6.48 g (91%) of the title compound.

Sources & evidence

ORD record
ord-d540dfa9ee104a65824678d8d5b62bc2
Source dataset
uspto-grants-2003_08
Patent number
US06605626B2

Reaction notes

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