Sodium borohydride → HCID 10155447, compound

HRID 395881Notes

Reaction equation

HRID 395881 reaction equation
[O:1]=[C:2]1[CH:7]2[CH2:8][CH2:9][CH:3]1[CH2:4][CH:5]([C:10]1[NH:18][C:17]3[C:16](=[O:19])[N:15]([CH2:20][CH2:21][CH3:22])[C:14](=[O:23])[N:13]([CH2:24][CH2:25][CH3:26])[C:12]=3[N:11]=1)[CH2:6]2.[BH4-].[Na+]>CO>[OH:1][CH:2]1[CH:7]2[CH2:8][CH2:9][CH:3]1[CH2:4][CH:5]([C:10]1[NH:18][C:17]3[C:16](=[O:19])[N:15]([CH2:20][CH2:21][CH3:22])[C:14](=[O:23])[N:13]([CH2:24][CH2:25][CH3:26])[C:12]=3[N:11]=1)[CH2:6]2

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18173103HCID 18173103, compound

Product 1

HCID 10155447HCID 10155447, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8-(8-Oxo-bicyclo[3.2.1]oct-3-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione (25 mg) was reduced using NaBH4 (30 mg) in MeOH at 0° C. The product was purified by HPLC. Yield (7 mg). Mass (ES+ 361).

Workup

  1. customat 0° C
  2. customThe product was purified by HPLC
  3. customYield (7 mg)

Sources & evidence

ORD record
ord-8d0b19adc88949aea9be93de95a92d38
Source dataset
uspto-grants-2003_08
Patent number
US06605600B1

Reaction notes

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