Ammonium Acetate → 3-(2-Fluoro-4-iodo-phenylamino)-2-methyl-isonicotinamide

HRID 39590Notes

Reaction equation

HRID 39590 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[C:18]([CH3:19])=[N:17][CH:16]=[CH:15][C:11]=1[C:12](O)=[O:13].C([O-])(=O)C.[NH4+:24]>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[C:18]([CH3:19])=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH2:24])=[O:13]

Participants

3

Reactant 2

HCID 517165Ammonium AcetateHCID 115524733-[(2-Fluoro-4-iodophenyl)amino]-2-methyl-isonicotinic acid

Product 1

HCID 116822133-(2-Fluoro-4-iodo-phenylamino)-2-methyl-isonicotinamide

Procedure

3-(2-Fluoro-4-iodo-phenylamino)-2-methyl-isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.2 mmol of 3-[(2-fluoro-4-iodophenyl)amino]-2-methyl-isonicotinic acid and 0.4 mmol of ammonium acetate. LC/MS [1.85 min; 372 (M+1)].

Workup

  1. customLC/MS [1.85 min; 372 (M+1)]

Sources & evidence

ORD record
ord-69d35c7053cb44a99c0b375bb8ec981d
Source dataset
uspto-grants-2013_09
Patent number
US08524911B2

Reaction notes

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