Ethanol → HCID 23381347, compound

HRID 395970Notes

Reaction equation

HRID 395970 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([NH:18][CH2:19][CH3:20])=[O:17])=[CH:11][CH:10]=1)[C:2]1C=CC=C[CH:3]=1.[H][H].C([OH:25])C>[Pd]>[CH2:19]([NH:18][C:16]([NH:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:1][C@@H:2]2[CH2:3][O:25]2)=[CH:10][CH:11]=1)=[O:17])[CH3:20]

Participants

5

Reactant 3

HCID 702EthanolHCID 18173649HCID 18173649, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23381347HCID 23381347, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

N-[4-(Benzyloxy)phenyl]-N′-ethylurea (6.3 g, 23.30 mmol) was dissolved in ethanol (150 mL). 10% Palladium on carbon (0.6 g) was added and the mixture shaken overnight under 50 psi hydrogen on a Parr apparatus. The solution was filtered through a Celite pad, the residue washed with ethanol and the solvent removed in vacuo to yield the title compound (3.84 g, 21.2 mmol).

Workup

  1. filtrationThe solution was filtered through a Celite pad
  2. washthe residue washed with ethanol
  3. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-30ef377ce3df48559d82320135d9bdd6
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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