Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10166207, compound

HRID 396017Notes

Reaction equation

HRID 396017 reaction equation
[NH2:1][CH2:2][CH2:3][O:4][C:5]1[CH:28]=[CH:27][C:8]([NH:9][CH:10]2[CH2:15][CH2:14][N:13]([C:16]([NH:18][CH2:19][C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)=[O:17])[CH2:12][CH2:11]2)=[CH:7][CH:6]=1.C([Si]([O:46][C:47]1[CH:52]=[CH:51][C:50]([O:53][CH2:54][CH:55]2[CH2:57][O:56]2)=[CH:49][CH:48]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[F:26][C:23]1[CH:22]=[CH:21][C:20]([CH2:19][NH:18][C:16]([N:13]2[CH2:14][CH2:15][CH:10]([NH:9][C:8]3[CH:7]=[CH:6][C:5]([O:4][CH2:3][CH2:2][NH:1][CH2:57][C@H:55]([OH:56])[CH2:54][O:53][C:50]4[CH:51]=[CH:52][C:47]([OH:46])=[CH:48][CH:49]=4)=[CH:28][CH:27]=3)[CH2:11][CH2:12]2)=[O:17])=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18173882HCID 18173882, compound

Product 1

HCID 10166207HCID 10166207, compoundYield 11.5%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[4-(2-Aminoethoxy)anilino]-N-(4-fluorobenzyl)-1-piperidinecarboxamide (0.63 g, 1.4 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.53 g, 1.3 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.125 g, 0.15 mmol).

Sources & evidence

ORD record
ord-39579c2c29a34e0892488bb2a8c88d2b
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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