HCID 22713353, compound → HCID 22713410, compound

HRID 396094Notes

Reaction equation

HRID 396094 reaction equation
[N:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:25][CH2:24][C:19]4(OCC[O:20]4)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)=O>[N:1]1([S:7]([C:10]2[CH:11]=[CH:12][C:13]([N:16]3[CH2:17][CH2:18][C:19](=[O:20])[CH2:24][CH2:25]3)=[CH:14][CH:15]=2)(=[O:9])=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 1

HCID 22713353HCID 22713353, compound

Product 1

HCID 22713410HCID 22713410, compoundYield 79.5%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Conditions

Temperature
60 °C

Procedure

8-[4-(1-Piperidinylsulfonyl)phenyl]-1,4-dioxa-8-azaspiro[4.5]decane (1.0 g, 2.73 mmol) was dissolved in formic acid and heated at 60° C. for 1 hour. The solvent was removed in vacuo and the residue crystallized from ethanol to give the title compound (0.70 g, 2.17 mmol).

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue crystallized from ethanol

Sources & evidence

ORD record
ord-7b54b6aba89d466193253aa5632b1da1
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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