HCID 178428763, compound → HCID 178428502, compound

HRID 396138Notes

Reaction equation

HRID 396138 reaction equation
[CH3:1][C:2]1[CH:21]=[C:20]([N+:22]([O-])=O)[CH:19]=[C:18]([CH3:25])[C:3]=1[O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][N:9]=[C:8]2[CH2:14][CH:15]([CH3:17])[CH3:16]>C(O)C.[Pd]>[NH2:22][C:20]1[CH:21]=[C:2]([CH3:1])[C:3]([O:4][C:5]2[CH:6]=[C:7]3[C:11](=[CH:12][CH:13]=2)[NH:10][N:9]=[C:8]3[CH2:14][CH:15]([CH3:17])[CH3:16])=[C:18]([CH3:25])[CH:19]=1

Participants

4

Reactant 1

HCID 178428763HCID 178428763, compound

Product 1

HCID 178428502HCID 178428502, compoundYield 64%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

In an analogous manner to the procedure of Example 1, 172 mg (0.507 mmol) of 5-(2,6-dimethyl-4-nitrophenoxy)-3-isobutyl-1H-indazole are reacted with 25 mg of palladium/carbon (10%) in 15 ml of ethanol under hydrogen in the course of 3 h to give 100 mg (64%) of 5-(4-amino-2,6-dimethylphenoxy)-3-isobutyl-1H-indazole.

Sources & evidence

ORD record
ord-caa78f53330943c88f24114283e00315
Source dataset
uspto-grants-2003_08
Patent number
US06608049B2

Reaction notes

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