Sodium ethoxide → HCID 178428669, compound

HRID 396141Notes

Reaction equation

HRID 396141 reaction equation
C([O:3][C:4](=[O:37])[C:5]([NH:7][C:8]1[CH:34]=[C:33]([CH3:35])[C:11]([O:12][C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[N:18](C(=O)C(OCC)=O)[N:17]=[C:16]3[CH2:29][CH:30]([CH3:32])[CH3:31])=[C:10]([CH3:36])[CH:9]=1)=[O:6])C.[O-]CC.[Na+]>C(O)C>[CH3:36][C:10]1[CH:9]=[C:8]([NH:7][C:5](=[O:6])[C:4]([OH:37])=[O:3])[CH:34]=[C:33]([CH3:35])[C:11]=1[O:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][N:17]=[C:16]2[CH2:29][CH:30]([CH3:32])[CH3:31]

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 21353737HCID 21353737, compound

Product 1

HCID 178428669HCID 178428669, compoundYield 31.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In an analogous manner to the procedure of Example 9, 47 mg (0.092 mmol) of ethyl [5-(4-{[ethoxy(oxo)acetyl]amino}-2,6-dimethylphenoxy)-3-isobutyl-1H-indazol-1-yl](oxo)acetate in 10 ml of ethanol are reacted with a spatula-tipful of sodium ethoxide to give 11 mg (31%) of ({3,5-dimethyl-4-[(3-isobutyl-1H-indazol-5-yl)oxy]phenyl}amino) (oxo)acetic acid.

Sources & evidence

ORD record
ord-e18b887e6a274fdda0083834d6ed3b83
Source dataset
uspto-grants-2003_08
Patent number
US06608049B2

Reaction notes

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